Bioinformatics
Bioinformatics is the mathematical, statistical and computational analysis of biological data, that aims to solve biochemical problems. Our main interest is now focused on genomic signature, mutations, and transfers in genes.
A variety of data analysis concerned with genome sequences support the proposal that each living organism owns a genomic signature. Classical approaches to the genomic signature deciphering are based on the counting of oligonucleotides in DNA sequences. Statistical tools as well as graphical representations have been used to associate genomic signatures with oligonucleotides frequencies in the genome. Moreover, many experimental results also show that the core features characterizing the whole genome are preserved in short subsequences, validating the idea of a genomic signature.
Our research are now focused on a new method to detect the genomic signature, based on a mathematical representation of trinucleotide frequencies, that maintains the essential properties of the signature itself providing, at the same time, a more formal instrument of analysis. Spline and B-spline functions are used in order to obtain a graphical 2D representation of the signature and an analytical expression used for formal mathematical, statistic and probabilistic analyses.
The same approach can be used in order to disclose mutations, HGTs, and SNPs in genes...
Contacts
Address: Dipartimento di Informatica ed Applicazioni "R. M. Capocelli"
Università degli Studi di Salerno
Via Ponte don Melillo - 84084 Fisciano, Salerno (Italy).
email: iaccarino[@]dia[.]unisa[.]it (without [] antispam)
